KSRP & EGFR in Lung cancer

Background

Recent studies have identified the splicing and RNA stability & translation regulating protein KSRP as a potential regulator of cancer. We have previosly shown the involvement of this protein in RNA stability and translation control in inflammation. Knock down of KSRP leads to upregulation of EGFR ligand mRNAs and KSRP associates with these mRNAs and potentially participates in posttrancriptional control of EGFR signaling. The potential mechanisms of this pathway is being investigated here

References

Bae JA, Bae WK, Kim SJ, Ko YS, Kim KY, Park SY, Yu YH, Kim EA, Chung IJ, Kim H, Ha HH, Kim KK. A new KSRP-binding compound suppresses distant metastasis of colorectal cancer by targeting the oncogenic KITENIN complex. Mol Cancer. 2021 May 26;20(1):78.
Dhamija S, Kuehne N, Winzen R, Doerrie A, Dittrich-Breiholz O, Thakur BK, Kracht M & Holtmann H (2011) Interleukin-1 activates synthesis of interleukin-6 by interfering with a KSRP-dependent translational silencing mechanism. J Biol Chem 286: 33279-33288.
Dhamija S, Doerrie A, Winzen R, Dittrich-Breiholz O, Taghipour A, Kuehne N, Kracht M & Holtmann H (2010) IL-1-induced post-transcriptional mechanisms target overlapping translational silencing and destabilizing elements in IκBzeta mRNA.J Biol Chem 285: 29165-29178.
Winzen R, Thakur BK, Dittrich-Breiholz O, Shah M, Redich N, Dhamija S,Kracht M & Holtmann H (2007) Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 & identification of inflammatory mRNA targets. Mol Cell Biol 27: 8388-8400.

Funding

DST SERB grant & CSIR-IGIB intramural funds